Brain Metastatic Cell Line
Summary
Metastatic brain cancer is a serious lethal complication of breast, prostate, and other cancers. There are rare cell lines available that metastasize to the brain in vivo. A cell line (Leo) has been developed that metastasizes to the brain and spinal cord after injection into left cardiac ventricle of immunodeficient mice. Most mice (80%) develop multifocal brain tumors that enlarge progressively. The Leo cells were isolated from a dog with prostate cancer. The Leo cells also metastasize to bone and adrenal glands, but at a lower incidence (20%). The Leo cells have been transduced with luciferase to permit in vivo bioluminescent imaging. The new Leo cell line will be a valuable model to investigate the mechanisms of brain metastasis in vivo.
Main Advantages of Technical Approach
- Companies that market cell lines to cancer and metastasis researchers.
- Pharmaceutical companies.
Market Potential
- The Leo cell line grows well in vitro and is transducible.
- The Leo cells metastasize to the brain and spinal cord in immunodeficient mice with high incidence (>80%).
- Brain metastases are the cause of early removal or death.
- The Leo cells are stably transduced with luciferase to permit in vivo bioluminescent imaging.
Inventor
Thomas RosolIntellectual Property Status
Research ToolContact Information
Jane Newnew.16@osu.edu | 614-292-3911
Technology Licensing & Commercialization
The Ohio State University
1216 Kinnear Road
Columbus, OH 43212-1154
